Human cervicovaginal fluid biomarkers to predict term and preterm labor
نویسندگان
چکیده
منابع مشابه
Human cervicovaginal fluid biomarkers to predict term and preterm labor
Preterm birth (PTB; birth before 37 completed weeks of gestation) remains the major cause of neonatal morbidity and mortality. The current generation of biomarkers predictive of PTB have limited utility. In pregnancy, the human cervicovaginal fluid (CVF) proteome is a reflection of the local biochemical milieu and is influenced by the physical changes occurring in the vagina, cervix and adjacen...
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Background: Preterm birth is a common problem in obstetrics. Objective: To measure maternal serum interlukin-6 in mothers with preterm uterine contractions and compare it with cervicovaginal interlukin-6 in the same women. Methods: In this cross-sectional study, we measured interlukin-6 in the sera and cervicovaginal fluids of 86 women with preterm uterine contractions. All participants had an ...
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During pregnancy there is an alteration in maternal immunity within the uterus where innate, proinflammatory immune responses are tightly regulated to prevent immunological rejection of the fetal allograft. Disruption of the delicate balance of cytokines by bacteria or other factors increases the production of proinflammatory cytokines at the maternal-fetal interface and activates the parturiti...
متن کاملIdentification of Protein Biomarkers for Cervical Cancer Using Human Cervicovaginal Fluid
OBJECTIVES Cervicovaginal fluid (CVF) can be considered as a potential source of biomarkers for diseases of the lower female reproductive tract. The fluid can easily be collected, thereby offering new opportunities such as the development of self tests. Our objective was to identify a CVF protein biomarker for cervical cancer or its precancerous state. METHODS A differential proteomics study ...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2015
ISSN: 1664-042X
DOI: 10.3389/fphys.2015.00151